炎症小体作为微生物感应器。
Inflammasomes as microbial sensors.
机构信息
University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA.
出版信息
Eur J Immunol. 2010 Mar;40(3):611-5. doi: 10.1002/eji.200940180.
PMID:20201013
Abstract
Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.
摘要
Nod 样受体家族成员和衔接子 ASC 组装成多蛋白平台，称为炎性小体，以介导 caspase-1 的激活以及随后的 IL-1β和 IL-18 的分泌。最近的研究已经确定了参与炎性小体激活的微生物和内源性分子以及可能的机制。
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