Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.
Eur J Immunol. 2010 Mar;40(3):624-7. doi: 10.1002/eji.200940211.
Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.
近年来，我们对 NOD 样受体 (NLR) 的认识取得了显著进展，NLR 是先天和适应性免疫中具有核心作用的细胞内传感器。大多数研究都集中在 caspase-1 炎性小体上。然而，哺乳动物 NLR 家族的几个成员在炎症小体信号之外的免疫中发挥着重要作用。在这里，我们强调了其中几个 NLR 的新作用。
