ROS 通过信号转导驱动炎症小体激活。
Signaling by ROS drives inflammasome activation.
机构信息
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Eur J Immunol. 2010 Mar;40(3):616-9. doi: 10.1002/eji.200940168.
Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.
炎症小体是先天免疫信号通路，可识别病原体和损伤，从而指导炎症细胞因子（如白细胞介素-1β和白细胞介素-18）的蛋白水解成熟。在炎症小体中，NLRP3/NALP3 炎症小体是研究最多的。然而，介导其组装和激活的分子机制知之甚少。最近的研究结果表明，ROS 是由 NLRP3/NALP3 激活剂产生的，是 NLRP3/NALP3 炎症小体激活的重要二级信使。
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