Adjuvant Research group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.
Eur J Immunol. 2010 Mar;40(3):634-8. doi: 10.1002/eji.200940172.
Adjuvants are essential for enhancing and directing immunity to vaccine antigens. Most adjuvants in clinical use are particulates, but how they drive innate and adaptive immune responses is unclear. A major recent advance was the demonstration that particulate adjuvants promote activation of the NLRP3 inflammasome. The mechanisms underlying this activation have been partly resolved and the role of NLRP3 in particulate adjuvant-induced adaptive immunity is currently the subject of intense interest.
佐剂对于增强和引导疫苗抗原的免疫应答至关重要。大多数临床使用的佐剂都是颗粒剂，但它们如何驱动先天和适应性免疫应答尚不清楚。最近的一项重大进展是证明颗粒佐剂可促进 NLRP3 炎性小体的激活。这种激活的机制部分得到了解决，NLRP3 在颗粒佐剂诱导的适应性免疫中的作用目前是研究的热点。
