Unit of Innate Immunity, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Int Immunopharmacol. 2011 May;11(5):549-54. doi: 10.1016/j.intimp.2010.11.025. Epub 2010 Nov 27.
It is well known that the innate immune system can induce and regulate the development of adaptive immunity. The NLRP3 inflammasome is a multiprotein complex that controls the caspase-1 activation step that is a pre-requisite for the maturation of interleukin (IL)-1β and IL-18. Recent findings showed that the NLRP3 inflammasome not only is an innate responder to pathogenic and danger signals, but also can affect the adaptive immune response. Here we review the role of NLRP3 inflammasome in regulating adaptive immunity.
众所周知，先天免疫系统可以诱导和调节适应性免疫的发展。NLRP3 炎性小体是一种多蛋白复合物，控制半胱天冬酶-1 的激活步骤，这是白细胞介素 (IL)-1β 和 IL-18 成熟的必要条件。最近的研究结果表明，NLRP3 炎性小体不仅是对病原体和危险信号的先天反应者，而且还可以影响适应性免疫反应。在这里，我们回顾了 NLRP3 炎性小体在调节适应性免疫中的作用。
