Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Eur J Immunol. 2010 Mar;40(3):607-11. doi: 10.1002/eji.200940207.
Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non-microbial insults causes the activation of nucleotide-binding domain leucine-rich repeat containing receptors in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses.
通过模式识别受体，先天免疫系统检测到机体正常功能的破坏，并启动旨在纠正这些异常的反应。微生物或非微生物损伤导致核苷酸结合域富含亮氨酸重复序列受体在多蛋白复合物（称为炎性小体）中的激活。在这里，我们讨论了 NLRP3 炎性小体在识别细胞损伤和启动无菌性炎症反应中的作用。
