Ciocoiu Manuela, Miron Anca, Bădescu Magda
Facultatea de Medicină, Disciplina de Fiziopatologie, Universitatea de Medicină si Farmacie "Gr. T. Popa" Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2008 Jul-Sep;112(3):757-63.
The paper focuses on the extraction and purification by chromatographic and spectral methods of certain natural polyphenolic extracts from Aronia melanocarpa and common elder (Sambuccus nigra) fruit, and also on their effects in hypoinsulinemic diabetes mellitus.
The research was made upon Wistar rats, which were divided into 4 groups: group I--control group; group II--with polyphenols in a dose of 0.034 g/body-kg; group III--with diabetes mellitus, induced by 55 mg/body-kg of streptozotocyne; group IV--to whom was administered a solution of polyphenols, 12 weeks, after the onset of diabetes mellitus.
Glycosylated hemoglobin values are much higher in the diabetic group and they are significantly lower in the group protected by polyphenols. The serous activity of glutathione-peroxidase and superoxide-dismutase has significantly lower values in the diabetic group as compared to the group protected by polyphenols. The serous concentration of malondialdehyde in the diabetic group undergoing polyphenols treatment is lower as compared to the diabetic group, which means a significant decrease of lipid peroxides in the serum. The results demonstrate the hypoglycemic, hypolipemic and antioxidant effects of Aronia melanocarpa and Sambucus nigra extracts in streptozocin-induced diabetes.
本文重点研究了通过色谱和光谱方法从黑果腺肋花楸和接骨木（黑接骨木）果实中提取和纯化某些天然多酚提取物，以及它们对胰岛素缺乏型糖尿病的影响。
对Wistar大鼠进行研究，将其分为4组：第一组——对照组；第二组——给予剂量为0.034 g/体千克的多酚；第三组——用55 mg/体千克链脲佐菌素诱导糖尿病；第四组——在糖尿病发病后12周给予多酚溶液。
糖尿病组糖化血红蛋白值高得多，而受多酚保护的组则显著降低。与受多酚保护的组相比，糖尿病组谷胱甘肽过氧化物酶和超氧化物歧化酶的血清活性值显著降低。接受多酚治疗的糖尿病组血清丙二醛浓度低于糖尿病组，这意味着血清中脂质过氧化物显著减少。结果表明，黑果腺肋花楸和黑接骨木提取物对链脲佐菌素诱导的糖尿病具有降血糖、降血脂和抗氧化作用。
