Department of Pathophysiology, University of Medicine and Pharmacy Gr.T.Popa Iasi, Romania.
J Physiol Biochem. 2009 Sep;65(3):297-304. doi: 10.1007/BF03180582.
The paper focuses on certain natural polyphenolic extracts from common elder fruit (Sambucus nigra), and also on their effects in diabetes mellitus. The results reveal that the glycosylated hemoglobin values are much higher in the diabetic group and they are significantly lower in the group protected by polyphenols. The natural polyphenol compounds reduce the lipids peroxides, neutralize the lipid peroxil radicals and inhibit the LDL oxidation. Following the perturbation of the lipid metabolism in the diabetic rats, atherogen risk has significantly increased values in comparison to the rats from the witness groups. It is found that due to the polyphenolic protection of the rats from the diabetic group treated with polyphenols, the atherogen risk is preserved at normal limits. The serum activity of glutathione-peroxidase and superoxide-dismutase has significantly lower values in the diabetic group as compared to the group protected by polyphenols. Through the hypoglycemiant, hypolipemiant and antioxidant effects,Sambucus nigra represents a possible dietary adjunct for the treatment of diabetes and a potential source for the discovery of new orally active agent(s) for future diabetes therapy. Understanding the mechanism through which the natural polyphenols have effects on the functionality of the endothelium cells, including on the membrane sensitivity and intracellular signalling, could represent a new way of therapeutically approaching chronic metabolic diseases and cardiovascular illnesses.
本文主要关注常见接骨木果实（黑接骨木）中的某些天然多酚提取物及其在糖尿病中的作用。结果表明，糖尿病组的糖化血红蛋白值明显较高，而经多酚保护的组则明显较低。天然多酚化合物可降低脂质过氧化物，中和脂质过氧自由基，并抑制 LDL 氧化。与对照组大鼠相比，糖尿病大鼠的脂质代谢紊乱导致动脉粥样硬化风险显著增加。结果发现，由于多酚对糖尿病组大鼠的保护作用，动脉粥样硬化风险保持在正常范围内。与多酚保护组相比，糖尿病组血清谷胱甘肽过氧化物酶和超氧化物歧化酶的活性明显较低。黑接骨木具有降血糖、降血脂和抗氧化作用，可作为治疗糖尿病的饮食辅助剂，也可能成为未来糖尿病治疗的新型口服药物的潜在来源。了解天然多酚对内皮细胞功能的作用机制，包括对膜敏感性和细胞内信号转导的影响，可能为治疗慢性代谢性疾病和心血管疾病提供一种新的治疗方法。
