Biomedical Engineering Center, Hunan University, Changsha, Hunan 410082, China.
J Biomed Nanotechnol. 2009 Oct;5(5):536-41. doi: 10.1166/jbn.2009.1064.
High-concentration gold nanoparticles stabilized by poly(vinylpyrrolindone) (PVP) are prepared through modified citrate-reduction method. The modified approach possesses all the advantages of the popular citrate reduction method. With PVP as weak ligands as well as spatial effects for the metal nanoparticles, the control of the size and size distribution of the gold nanoparticles in the size range between 10 and 30 nm was achieved via maintaining balanced nucleation and growth by tuning the feed ratios of the metal precursors and reducing reagents. As a modified procedure to gold nanoparticles, PVP-stabilized gold nanoparticles are more stable in a broad range of pH and different buffers than conventional gold colloids. Because only PVP are employed in the new synthetic schemes, surface modification and functionalization of the resulting gold nanoparticles through small molecular ligands can be readily carried out.
通过改良的柠檬酸钠还原法制备了由聚乙烯吡咯烷酮（PVP）稳定的高浓度金纳米粒子。改良方法具备了流行的柠檬酸钠还原法的所有优点。PVP 既作为弱配体，又作为金属纳米粒子的空间位阻稳定剂，通过调节金属前驱体和还原剂的进料比来控制金纳米粒子的尺寸和尺寸分布在 10 到 30nm 的范围内，从而实现成核和生长的平衡。作为金纳米粒子的一种改良方法，与传统的金胶体相比，PVP 稳定的金纳米粒子在更宽的 pH 范围和不同的缓冲液中更加稳定。由于在新的合成方案中仅使用 PVP，因此可以通过小分子配体很容易地对所得金纳米粒子进行表面改性和功能化。
