Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering , Shanghai Jiao Tong University , 800 Dongchuan RD , Shanghai 200240 , China.
Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument , 800 Dongchuan RD , Shanghai 200240 , China.
Bioconjug Chem. 2018 Jun 20;29(6):2120-2125. doi: 10.1021/acs.bioconjchem.8b00349. Epub 2018 May 29.
Cell lines were exposed either to mixtures of gold and iron oxide nanoparticles, or to a hybrid nanoparticle with gold and iron oxide domain. In the case of simultaneous exposure to gold and iron oxide nanoparticles, enhanced toxicity as compared to the exposure to only one type of nanoparticles was observed. An indication was found that, at equivalent concentrations, the hybrid nanoparticles may slightly reduce cell viability more strongly than mixtures of both nanoparticle types. The results suggest that composite nanomaterials, in which different materials are present in particle form, need to be analyzed carefully, as not only the concentration of the respective materials but also their arrangement may influence their toxicity.
细胞系暴露于金和氧化铁纳米粒子的混合物中，或暴露于具有金和氧化铁域的混合纳米粒子中。在同时暴露于金和氧化铁纳米粒子的情况下，与仅暴露于一种类型的纳米粒子相比，观察到毒性增强。结果表明，在等效浓度下，与两种纳米粒子类型的混合物相比，混合纳米粒子可能略微更强烈地降低细胞活力。结果表明，复合材料纳米材料（其中不同的材料以颗粒形式存在）需要仔细分析，因为不仅要考虑各自材料的浓度，还要考虑它们的排列方式，这可能会影响它们的毒性。
