Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, SE-100 44, Stockholm, Sweden.
Biomacromolecules. 2010 Apr 12;11(4):855-63. doi: 10.1021/bm9011248.
Two-, four-, and six-armed branched copolymers with electroactive and biodegradable properties were synthesized by coupling reactions between poly(l-lactides) (PLLAs) with different architecture and carboxyl-capped aniline trimer (CCAT). The aniline oligomer CCAT was prepared from amino-capped aniline trimer and succinic anhydride. FT-IR, NMR, and SEC analyses confirmed the structure of the branched copolymers. UV-vis spectra and cyclic voltammetry of CCAT and copolymer solution showed good electroactive properties, similar to those of polyaniline. The water contact angle of the PLLAs was the highest, followed by the undoped copolymer and the doped copolymers. The values of doped four-armed copolymers were 54-63 degrees . Thermal properties of the polymers were studied by DSC and TGA. The copolymers had better thermal stability than the pure PLLAs, and the T(g) between 48-58 degrees C and T(m) between 146-177 degrees C of the copolymers were lower than those of the pure PLLA counterparts. This kind of electroactive and biodegradable copolymer has a great potential for applications in cardiovascular or neuronal tissue engineering.
通过聚（L-丙交酯）（PLLA）与不同结构的羧基封端的苯胺三聚体（CCAT）的偶联反应，合成了具有电活性和可生物降解性能的二臂、四臂和六臂支化共聚物。CCAT 是由氨基封端的苯胺三聚体和琥珀酸酐制备的。FT-IR、NMR 和 SEC 分析证实了支化共聚物的结构。CCAT 和共聚物溶液的紫外可见光谱和循环伏安法表明具有良好的电活性，类似于聚苯胺。PLLA 的水接触角最高，其次是未掺杂的共聚物和掺杂的共聚物。掺杂的四臂共聚物的值为 54-63 度。通过 DSC 和 TGA 研究了聚合物的热性能。与纯 PLLA 相比，共聚物具有更好的热稳定性，共聚物的 T(g)在 48-58°C 之间，T(m)在 146-177°C 之间，低于纯 PLLA 对应物的 T(g)和 T(m)。这种具有电活性和可生物降解的共聚物在心血管或神经组织工程中有很大的应用潜力。
