Huang Lihong, Hu Jun, Lang Le, Wang Xin, Zhang Peibiao, Jing Xiabin, Wang Xianhong, Chen Xuesi, Lelkes Peter I, Macdiarmid Alan G, Wei Yen
State key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Biomaterials. 2007 Apr;28(10):1741-51. doi: 10.1016/j.biomaterials.2006.12.007. Epub 2007 Jan 10.
A triblock copolymer PLA-b-AP-b-PLA (PAP) of polylactide (PLA) and aniline pentamer (AP) with the unique properties of being both electroactive and biodegradable is synthesized by coupling an electroactive carboxyl-capped AP with two biodegradable bi-hydroxyl-capped PLAs via a condensation reaction. Three different molecule weight PAP copolymers are prepared. The PAP copolymers exhibit excellent electroactivity similar to the AP and polyaniline, which may stimulate cell proliferation and differentiation. The electrical conductivity of the PAP2 copolymer film ( approximately 5x10(-6)S/cm) is in the semiconducting region. Transmission electron microscopic results suggest that there is microphase separation of the two block segments in the copolymer, which might contribute to the observed conductivity. The biodegradation and biocompatibility experiments in vitro prove the copolymer is biodegradable and biocompatible. Moreover, these new block copolymer shows good solubility in common organic solvents, leading to the system with excellent processibility. These biodegradable PAP copolymers with electroactive function thus possess the properties that would be potentially used as scaffold materials for neuronal or cardiovascular tissue engineering.
通过缩合反应将具有电活性的羧基封端苯胺五聚体（AP）与两个可生物降解的双羟基封端聚乳酸（PLA）偶联，合成了具有电活性和可生物降解独特性能的聚乳酸-苯胺五聚体-聚乳酸三嵌段共聚物（PAP）。制备了三种不同分子量的PAP共聚物。PAP共聚物表现出与AP和聚苯胺相似的优异电活性，这可能刺激细胞增殖和分化。PAP2共聚物薄膜的电导率（约5×10⁻⁶S/cm）处于半导体区域。透射电子显微镜结果表明共聚物中两个嵌段存在微相分离，这可能是观察到的电导率的原因。体外生物降解和生物相容性实验证明该共聚物具有生物可降解性和生物相容性。此外，这些新型嵌段共聚物在常见有机溶剂中具有良好的溶解性，使得该体系具有优异的加工性能。因此，这些具有电活性功能的可生物降解PAP共聚物具有潜在用作神经或心血管组织工程支架材料的特性。
