流致弥散分析定量纳米升样品中非共价相互作用。
Flow induced dispersion analysis quantifies noncovalent interactions in nanoliter samples.
机构信息
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
出版信息
J Am Chem Soc. 2010 Mar 31;132(12):4070-1. doi: 10.1021/ja100484d.
PMID:20201527
Abstract
Flow Induced Dispersion Analysis (FIDA) is presented as a new approach to characterize noncovalent interactions. The new method only requires nanoliter samples, is easy to implement, and also provides diffusivities of the free analyte and the formed complex. The technique is based on signal analysis of temporal variances obtained for pressure driven flows in micrometer sized fused silica capillaries.
摘要
流动诱导分散分析（FIDA）被提出作为一种新的方法来描述非共价相互作用。新方法仅需要纳升级样品，易于实现，并且还提供了游离分析物和形成的复合物的扩散系数。该技术基于在微尺寸熔融二氧化硅毛细管中驱动流动时获得的时间方差的信号分析。
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