Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, China.
Macromol Biosci. 2011 May 12;11(5):576-89. doi: 10.1002/mabi.201000427. Epub 2010 Dec 27.
Nanoparticulate drug-delivery systems have attained much importance because of their injectable property, the possibility to achieve passive targeting and active targeting, and unique advantages to realize stimuli tailored delivery. Molecular self-assembly is a powerful method for fabricating polymer-based nanoparticles, which involves various driving forces, such as hydrophobic interactions, electrostatic interactions, stereocomplexation, host/guest interactions and hydrogen bonding. By fine tuning one or many types of these interactions, self-assemblies with a wide range of structures and functions could be fabricated. In this article, recent developments in different self-assembly strategies for the preparation of polymer-based nanoparticulate delivery systems are discussed.
纳米颗粒药物递送系统因其可注射性、实现被动靶向和主动靶向的可能性以及实现定制刺激传递的独特优势而受到广泛关注。分子自组装是一种用于制备基于聚合物的纳米粒子的强大方法，它涉及各种驱动力，如疏水相互作用、静电相互作用、立体复合物形成、主体/客体相互作用和氢键。通过微调一种或多种类型的相互作用，可以制备具有广泛结构和功能的自组装体。本文讨论了用于制备基于聚合物的纳米颗粒递药系统的不同自组装策略的最新进展。
