Department of Immunology, University of Washington, Seattle, WA 98195, USA.
Immunology. 2010 Apr;129(4):467-73. doi: 10.1111/j.1365-2567.2010.03250.x. Epub 2010 Feb 26.
T-cell receptor (TCR) revision is a process of tolerance induction by which peripheral T cells lose surface expression of an autoreactive TCR, reinduce expression of the recombinase machinery, rearrange genes encoding extrathymically generated TCRs for antigen, and express these new receptors on the cell surface. We discuss the evidence for this controversial tolerance mechanism below. Despite the apparent heresy of post-thymic gene rearrangement, we argue here that TCR revision follows the rules obeyed by maturing thymocytes undergoing gene recombination. Expression of the recombinase is carefully controlled both spatially and temporally, and may be initiated by loss of signals through surface TCRs. The resulting TCR repertoire is characterized by its diversity, self major histocompatibility complex restriction, self tolerance, and ability to mount productive immune responses specific for foreign antigens. Hence, TCR revision is a carefully regulated process of tolerance induction that can contribute to the protection of the individual against invading pathogens while preserving the integrity of self tissue.
T 细胞受体 (TCR) 修正 是一种耐受诱导过程，在此过程中，外周 T 细胞失去自身反应性 TCR 的表面表达，重新诱导重组酶机制的表达，重新排列编码在外周产生的 TCR 的基因，并在细胞表面表达这些新受体。我们将在下面讨论这一有争议的耐受机制的证据。尽管在后胸腺基因重排方面存在明显的异端邪说，但我们在这里认为，TCR 修正遵循了成熟胸腺细胞进行基因重组所遵循的规则。重组酶的表达在空间和时间上都受到严格控制，并且可能是通过表面 TCR 失去信号而启动的。由此产生的 TCR 库的特点是其多样性、自身主要组织相容性复合物限制、自身耐受和对特异性外来抗原产生有效免疫反应的能力。因此，TCR 修正 是一种精心调控的耐受诱导过程，有助于保护个体免受入侵病原体的侵害，同时保持自身组织的完整性。
