Service of Hematology, University Hospital Son Dureta, Palma de Mallorca, Balearic Islands, Spain.
Int J Lab Hematol. 2010 Dec;32(6 Pt 2):582-9. doi: 10.1111/j.1751-553X.2010.01225.x.
CA125, a tumor marker normally used to follow the clinical course of ovarian cancer, also may have a role in lymphoma. All available series were analyzed using the standard reference value 35 U/ml, but age and sex may influence serum CA125 (sCA125) levels. We aim to study the prognostic value of serum CA125 (sCA125) levels in diffuse large B-cell lymphoma (DLBCL), considering the influence of age and sex on sCA125 levels. We investigated the relationship between sCA125 and clinical outcome after treatment in 42 patients with DLBCL, comparing both the standard (35 U/ml) and a new age and sex adjusted (sex/age-adjusted) reference value proposed by our group. We found that patients with elevated sCA125 levels had significantly more adverse prognostic factors at diagnosis, lower CR rates, higher relapse rates and worse survival. In the low-risk IPI categories, the presence of elevated sCA125 defined a particularly high-risk subgroup with poorer 3-year PFS when compared with patients with normal sCA125 levels. The use of a sex/age-adjusted reference value for sCA125 may increase the sensitivity to identify those patients with elevated sCA125 levels truly related to DLBCL activity.
CA125 是一种肿瘤标志物，通常用于监测卵巢癌的临床病程，也可能在淋巴瘤中发挥作用。所有可用的系列均使用标准参考值 35U/ml 进行分析，但年龄和性别可能会影响血清 CA125（sCA125）水平。我们旨在研究血清 CA125（sCA125）水平在弥漫性大 B 细胞淋巴瘤（DLBCL）中的预后价值，同时考虑年龄和性别对 sCA125 水平的影响。我们研究了 42 例 DLBCL 患者治疗后 sCA125 与临床结局的关系，比较了我们组提出的标准（35U/ml）和新的年龄和性别调整（性别/年龄调整）参考值。我们发现，sCA125 水平升高的患者在诊断时具有更多不良预后因素，CR 率较低，复发率较高，生存较差。在低危 IPI 类别中，与 sCA125 水平正常的患者相比，sCA125 升高的患者存在更高的特定高危亚组，3 年 PFS 较差。使用 sCA125 的性别/年龄调整参考值可能会提高识别与 DLBCL 活性真正相关的 sCA125 水平升高患者的敏感性。
