Farjaudon N, Pareyre C, Deysson G
C R Seances Soc Biol Fil. 1977;171(1):34-8.
Anaphasis may be slightly checked by various treatments which however result in a normal chromosomic separation. Griseofulvin exerts a direct though partial influence on the mitotic apparatus, which entails "pluripolar anaphasis"; on the other hand Ipecac alkaloïds act indirectly and produce "floating poles anaphases". Treatments combining griseofulvin with cepheline or tubulosine show that there is never any synergy between the two processes. These results support our hypothesis that floating poles anaphases are not a sign of slight C-mitotic action but only come from a lag between the appearance/disappearance of microtubules and that of chromosomes during anaphasis.
后期可能会受到各种治疗的轻微抑制,不过这些治疗会导致正常的染色体分离。灰黄霉素对有丝分裂器有直接但部分的影响,会导致“多极后期”;另一方面,吐根生物碱起间接作用,产生“浮动极后期”。将灰黄霉素与西非千里光碱或管箭毒碱联合使用的治疗表明,这两个过程之间从未有过协同作用。这些结果支持了我们的假设,即浮动极后期不是轻微C-有丝分裂作用的标志,而仅仅是后期微管出现/消失与染色体出现/消失之间的时间差所致。