Department of Urology, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
Int J Urol. 2010 May;17(5):462-5. doi: 10.1111/j.1442-2042.2010.02499.x. Epub 2010 Feb 25.
To evaluate the efficacy of low dose tamsulosin for facilitating spontaneous passage of ureteral stones in Japanese male patients.
A total of 71 patients with symptomatic ureteral stones, 10 mm or smaller in size, were randomly allocated into groups 1 and 2. Group 1 received tamsulosin (0.2 mg/day) for a maximum of 4 weeks and group 2 received no medication. The primary endpoint was the stone expulsion rate and the secondary endpoints were stone expulsion time and analgesic use.
There were no significant differences between the groups in terms of age, stone size and location. The stone expulsion rate was significantly higher in group 1 than in group 2 (77% vs 50%, P = 0.002). No significant differences were noted in the stone expulsion time and analgesic use between the groups.
Low dose tamsulosin can significantly facilitate spontaneous passage of ureteral stones without significant side-effects in Japanese male patients.
评估低剂量坦索罗辛促进日本男性患者输尿管结石自行排出的疗效。
将 71 例有症状的输尿管结石患者（大小为 10mm 或以下）随机分为 1 组和 2 组。1 组给予坦索罗辛（0.2mg/天），最多 4 周；2 组不给予药物治疗。主要终点是结石排出率，次要终点是结石排出时间和镇痛药物使用情况。
两组在年龄、结石大小和位置方面无显著差异。1 组的结石排出率明显高于 2 组（77%比 50%，P=0.002）。两组在结石排出时间和镇痛药物使用方面无显著差异。
低剂量坦索罗辛可显著促进日本男性患者输尿管结石自行排出，且无明显副作用。
