Department of Oral Pathology, School of Dentistry, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Mycoses. 2011 Jul;54(4):e130-5. doi: 10.1111/j.1439-0507.2009.01857.x. Epub 2010 Feb 24.
The aim of this study was to evaluate oral epithelial cells of the oral mucosa infected by Candida albicans using exfoliative cytology. Oral smears were collected from clinically normal-appearing mucosa by liquid-based exfoliative cytology of 60 individuals (30 patients with oral candidiasis and 30 healthy controls matched for age and gender) and analysed for morphologic and cytomorphometric technique. Morphologically, candida-infected epithelial cells exhibited nuclear enlargement, perinuclear rings, discrete orangeophilia, and cytoplasmic vacuoles. The cytomorphometric analysis demonstrated that the cytoplasmic area (CA) of the epithelial cells was diminished in patients undergoing candidiasis as compared to the non-infected controls. In addition, there was an augmentation in nuclear area (NA) and NA/CA area ratio. This study revealed that oral mucosa of patients undergoing candidal infection exhibited significant changes in the size and shape of the oral epithelial cells.
本研究旨在通过脱落细胞学评估口腔黏膜被白念珠菌感染的口腔上皮细胞。通过液基细胞学从 60 名个体（30 名口腔念珠菌病患者和 30 名年龄和性别匹配的健康对照者）的临床正常黏膜中采集口腔涂片，并进行形态学和细胞计量技术分析。形态学上，受念珠菌感染的上皮细胞表现出核增大、核周晕环、离散的嗜橙性和细胞质空泡。细胞计量分析显示，与未受感染的对照组相比，念珠菌感染患者的上皮细胞胞质面积（CA）减少。此外，核面积（NA）和 NA/CA 面积比增加。本研究表明，患有念珠菌感染的口腔黏膜患者的口腔上皮细胞大小和形状发生了显著变化。
