可卡因对口腔黏膜影响的细胞形态计量学分析
Cytomorphometric analysis of crack cocaine effects on the oral mucosa.
作者信息
Woyceichoski Iverson Ernani Cogo, de Arruda Elcy Pinto, Resende Luciane Grochocki, Machado Maria Angela Naval, Grégio Ana Maria Trindade, Azevedo Luciana Reis, de Lima Antonio Adilson Soares
机构信息
Department of Oral Pathology, School of Dentistry, Pontifical Catholic University of Paraná, Curitiba/PR, Brazil.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jun;105(6):745-9. doi: 10.1016/j.tripleo.2007.09.011. Epub 2008 Mar 4.
OBJECTIVE
This study assessed the effect of smoking crack cocaine on the nuclear area (NA), the cytoplasmic area (CA), and the nucleus-to-cytoplasm area ratio (NA/CA) of oral squamous epithelial cells.
STUDY DESIGN
Oral smears were collected from clinically normal-appearing mucosa by liquid-based exfoliative cytology of 40 individuals (20 crack users and 20 nonusers) and analyzed for quantitative techniques using an image analysis system.
RESULTS
Mean values of NA for experimental and control groups were, respectively, 49.85 microm(2) and 62.68 microm(2) (P < .01). CA showed the following mean values: 1820.9 microm(2) (experimental) and 1780.8 microm(2) (control). NA/CA for the experimental group was 0.03; the control group was 0.04 (P < .01).
CONCLUSION
This study revealed that crack cocaine was able to induce significant changes on the oral epithelial cells. Since this illicit drug is normally used in association with other risk factors for oral cancer (tobacco and alcohol), crack cocaine abusers should have frequent preventive oral exams.
目的
本研究评估吸食快克可卡因对口腔鳞状上皮细胞核面积（NA）、细胞质面积（CA）以及核质面积比（NA/CA）的影响。
研究设计
通过液基脱落细胞学方法，从40名个体（20名快克使用者和20名非使用者）临床外观正常的黏膜处采集口腔涂片，并使用图像分析系统进行定量技术分析。
结果
实验组和对照组的NA平均值分别为49.85平方微米和62.68平方微米（P <.01）。CA的平均值如下：1820.9平方微米（实验组）和1780.8平方微米（对照组）。实验组的NA/CA为0.03；对照组为0.04（P <.01）。
结论
本研究表明，快克可卡因能够引起口腔上皮细胞的显著变化。由于这种非法药物通常与口腔癌的其他风险因素（烟草和酒精）一起使用，快克可卡因滥用者应经常进行预防性口腔检查。
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