Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):610-2. doi: 10.1016/j.pnpbp.2010.02.021. Epub 2010 Mar 2.
Accumulating evidence suggests that the brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) are molecules involved in the pathophysiology of major depressive disorder and response of antidepressants. To examine both BDNF and TrkB protein levels and their relationship with psychopathology in patients with major depressive disorder, 55 physically healthy patients with major depressive disorder were compared with 53 healthy controls. The severity of major depression was assessed by the 17-item Hamilton Depression Rating Scale (HDRS). Serum BDNF and TrkB protein levels were measured with Enzyme-linked immunosorbent assay (ELISA) kits. After using the analysis of covariance (ANCOVA) with age adjustment, the results of this work showed that BDNF presented no significant difference (F((1,107))=0.149, p=0.701) but the TrkB protein level was significantly higher in depressive patients than in healthy controls (F((1,107))=4.043, p=0.047). These findings suggest that the serum TrkB protein level may play an important role in the psychopathology of major depression.
越来越多的证据表明，脑源性神经营养因子（BDNF）及其受体原肌球蛋白相关激酶 B（TrkB）是参与重度抑郁症病理生理学和抗抑郁药反应的分子。为了研究 BDNF 和 TrkB 蛋白水平及其与重度抑郁症患者精神病理学的关系，将 55 名身体健康的重度抑郁症患者与 53 名健康对照进行了比较。采用汉密尔顿抑郁评定量表（HDRS）第 17 项评估重度抑郁症的严重程度。采用酶联免疫吸附测定（ELISA）试剂盒测量血清 BDNF 和 TrkB 蛋白水平。经过年龄调整的协方差分析（ANCOVA）后，本研究结果表明 BDNF 无显著差异（F((1,107))=0.149，p=0.701），但抑郁患者的 TrkB 蛋白水平明显高于健康对照组（F((1,107))=4.043，p=0.047）。这些发现表明，血清 TrkB 蛋白水平可能在重度抑郁症的精神病理学中发挥重要作用。
