Department of Psychiatry, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.
Neuropsychobiology. 2012;65(2):65-9. doi: 10.1159/000328991. Epub 2012 Jan 5.
In this study, we investigated serum protein levels of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) in patients with bipolar disorder.
Over a 2-year period, 26 patients with bipolar I disorder (manic episode) and 56 healthy controls were recruited. The Young Mania Rating Scale scores of patients with bipolar mania were >26. Serum BDNF and TrkB protein levels were measured with ELISA kits.
Using ANCOVA with age adjustment, we found that there were no significant differences in serum BDNF protein levels between patients with bipolar mania and healthy controls (p = 0.582). In contrast, the serum TrkB protein level was significantly higher in bipolar mania patients than in healthy controls (p = 0.001), especially in women (p = 0.001). Of 26 patients with bipolar mania, 21 underwent a second measurement of serum BDNF and TrkB protein levels after a 4-week treatment with mood stabilizers. There were no significant changes in serum BDNF or TrkB protein levels.
These findings suggest that serum TrkB protein levels may play an important role in the psychopathology of bipolar mania. However, a larger sample size is needed to confirm these results.
在这项研究中，我们调查了双相情感障碍患者的血清脑源性神经营养因子（BDNF）及其受体原肌球蛋白相关激酶 B（TrkB）水平。
在 2 年期间，招募了 26 名患有 I 型双相情感障碍（躁狂发作）的患者和 56 名健康对照者。双相躁狂患者的 Young 躁狂评定量表评分>26。使用 ELISA 试剂盒测量血清 BDNF 和 TrkB 蛋白水平。
使用年龄调整的 ANCOVA，我们发现躁狂发作的双相情感障碍患者与健康对照组之间的血清 BDNF 蛋白水平无显著差异（p = 0.582）。相比之下，双相情感障碍躁狂发作患者的血清 TrkB 蛋白水平明显高于健康对照组（p = 0.001），尤其是女性（p = 0.001）。在 26 名双相情感障碍躁狂发作患者中，21 名在接受 4 周的心境稳定剂治疗后再次测量了血清 BDNF 和 TrkB 蛋白水平。血清 BDNF 或 TrkB 蛋白水平没有明显变化。
这些发现表明，血清 TrkB 蛋白水平可能在双相情感障碍躁狂症的发病机制中起重要作用。但是，需要更大的样本量来证实这些结果。
