Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, 703 19th Street S., Birmingham, AL 35294, USA.
Circ Res. 2010 Mar 5;106(4):647-58. doi: 10.1161/CIRCRESAHA.109.209957.
Circadian misalignment has been implicated in the development of obesity, diabetes mellitus, and cardiovascular disease. Time-of-day-dependent synchronization of organisms with their environment is mediated by circadian clocks. This cell autonomous mechanism has been identified within all cardiovascular-relevant cell types, including cardiomyocytes. Recent molecular- and genetic-based studies suggest that the cardiomyocyte circadian clock influences multiple myocardial processes, including transcription, signaling, growth, metabolism, and contractile function. Following an appreciation of its physiological roles, the cardiomyocyte circadian clock has recently been linked to the pathogenesis of heart disease in response to adverse stresses, such as ischemia/reperfusion, in animal models. The purpose of this review is therefore to highlight recent advances regarding the roles of the cardiomyocyte circadian clock in both myocardial physiology and pathophysiology (ie, health and disease).
昼夜节律紊乱与肥胖、糖尿病和心血管疾病的发生有关。生物体随环境昼夜变化的时间同步性由昼夜节律钟介导。这种细胞自主机制已在所有与心血管相关的细胞类型中得到确认，包括心肌细胞。最近的基于分子和遗传学的研究表明，心肌细胞的昼夜节律钟影响多种心肌过程，包括转录、信号转导、生长、代谢和收缩功能。在认识到其生理作用后，心肌细胞昼夜节律钟最近与动物模型中缺血/再灌注等不利应激引起的心脏病发病机制相关联。因此，本文的目的是强调心肌细胞昼夜节律钟在心肌生理学和病理生理学（即健康和疾病）中的作用的最新进展。
