临床免疫学：具有进化联系的罪魁祸首。
Clinical immunology: Culprits with evolutionary ties.
出版信息
Nature. 2010 Mar 4;464(7285):41-2. doi: 10.1038/464041a.
Abstract
The cellular organelles we know as mitochondria are thought to have originated as symbiotic bacteria. Indeed, the two use common mechanisms to trigger innate immune responses to injury and infection, respectively.
摘要
我们所知的细胞细胞器线粒体被认为是起源于共生细菌。事实上，两者分别利用共同的机制来触发对损伤和感染的固有免疫反应。
相似文献
1
Clinical immunology: Culprits with evolutionary ties.临床免疫学：具有进化联系的罪魁祸首。
Nature. 2010 Mar 4;464(7285):41-2. doi: 10.1038/464041a.
2
Circulating mitochondrial DAMPs cause inflammatory responses to injury.循环线粒体 DAMPs 引起损伤的炎症反应。
Nature. 2010 Mar 4;464(7285):104-7. doi: 10.1038/nature08780.
3
The mitochondrion--a Trojan horse that kicks off inflammation?线粒体——引发炎症的特洛伊木马？
N Engl J Med. 2010 Jun 3;362(22):2132-4. doi: 10.1056/NEJMcibr1003521.
4
Immunosuppression following surgical and traumatic injury.手术后和创伤后的免疫抑制。
Surg Today. 2010 Sep;40(9):793-808. doi: 10.1007/s00595-010-4323-z. Epub 2010 Aug 26.
5
Pure Mitochondrial DNA Does Not Activate Human Neutrophils in vitro.纯线粒体DNA在体外不会激活人类中性粒细胞。
Biochemistry (Mosc). 2015 May;80(5):629-35. doi: 10.1134/S0006297915050168.
6
Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure.趋化因子和线粒体产物激活中性粒细胞，在小鼠急性肝衰竭中放大器官损伤。
Hepatology. 2012 Nov;56(5):1971-82. doi: 10.1002/hep.25801. Epub 2012 Aug 21.
7
Mitochondrial damage associated molecular patterns from femoral reamings activate neutrophils through formyl peptide receptors and P44/42 MAP kinase.股骨扩髓屑中与线粒体损伤相关的分子模式通过甲酰肽受体和 P44/42 MAP 激酶激活中性粒细胞。
J Orthop Trauma. 2010 Sep;24(9):534-8. doi: 10.1097/BOT.0b013e3181ec4991.
8
N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways.N-甲酰肽通过ERK1/2和P38丝裂原活化蛋白激酶信号通路驱动线粒体损伤相关分子模式诱导的中性粒细胞活化。
Injury. 2015;46(6):975-84. doi: 10.1016/j.injury.2015.03.028. Epub 2015 Mar 17.
9
Neutrophils in sepsis: battle of the bands.脓毒症中的中性粒细胞：各显神通
Crit Care Med. 2013 Mar;41(3):925-6. doi: 10.1097/CCM.0b013e31828042d8.
10
The two-event construct of postinjury multiple organ failure.创伤后多器官功能衰竭的双事件结构
Shock. 2005 Dec;24 Suppl 1:71-4. doi: 10.1097/01.shk.0000191336.01036.fe.
引用本文的文献
1
Identifying biomarkers distinguishing sepsis after trauma from trauma-induced SIRS based on metabolomics data: a retrospective study.基于代谢组学数据鉴别创伤后脓毒症与创伤性全身炎症反应综合征的生物标志物：一项回顾性研究
Sci Rep. 2025 Apr 21;15(1):13748. doi: 10.1038/s41598-025-94701-y.
2
Early risk predictors of acute kidney injury and short-term survival during Impella support in cardiogenic shock.心源性休克患者使用 Impella 支持期间急性肾损伤和短期生存的早期风险预测因子。
Sci Rep. 2024 Jul 30;14(1):17484. doi: 10.1038/s41598-024-68376-w.
3
Identifying biomarkers deciphering sepsis from trauma-induced sterile inflammation and trauma-induced sepsis.识别生物标志物，以区分脓毒症与创伤引起的无菌性炎症和创伤性脓毒症。
Front Immunol. 2024 Jan 12;14:1310271. doi: 10.3389/fimmu.2023.1310271. eCollection 2023.
4
Surface toll-like receptor 9 on immune cells and its immunomodulatory effect.免疫细胞表面 Toll 样受体 9 及其免疫调节作用。
Front Immunol. 2023 Sep 1;14:1259989. doi: 10.3389/fimmu.2023.1259989. eCollection 2023.
5
Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity.针对 CXCL1 趋化因子信号通路治疗顺铂耳毒性。
Front Immunol. 2023 Mar 31;14:1125948. doi: 10.3389/fimmu.2023.1125948. eCollection 2023.
6
Linking nutrient sensing, mitochondrial function, and PRR immune cell signaling in liver disease.将营养感应、线粒体功能和 PRR 免疫细胞信号转导在肝病中的联系。
Trends Immunol. 2022 Nov;43(11):886-900. doi: 10.1016/j.it.2022.09.002. Epub 2022 Oct 7.
7
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention.炎症、表观遗传学和代谢汇聚到细胞衰老和老化：调节和干预。
Signal Transduct Target Ther. 2021 Jun 28;6(1):245. doi: 10.1038/s41392-021-00646-9.
8
Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing.探索 FPR1 的偏向激动剂作为编码危险感知的一种手段。
Cells. 2020 Apr 23;9(4):1054. doi: 10.3390/cells9041054.
9
Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients.TRAUMADORNASE 方案：一项前瞻性、随机、多中心、双盲、安慰剂对照临床试验，评估雾化用重组人脱氧核糖核酸酶治疗降低机械通气创伤患者中中重度低氧血症发生率的效果。
Trials. 2020 Mar 18;21(1):274. doi: 10.1186/s13063-020-4141-6.
10
Membrane TLR9 Positive Neutrophil Mediated MPLA Protects Against Fatal Bacterial Sepsis.膜TLR9阳性中性粒细胞介导的MPLA可预防致命性细菌败血症。
Theranostics. 2019 Aug 14;9(21):6269-6283. doi: 10.7150/thno.37139. eCollection 2019.
本文引用的文献
1
Circulating mitochondrial DAMPs cause inflammatory responses to injury.循环线粒体 DAMPs 引起损伤的炎症反应。
Nature. 2010 Mar 4;464(7285):104-7. doi: 10.1038/nature08780.
2
Regulation of adaptive immunity by the innate immune system.先天免疫系统对适应性免疫的调节。
Science. 2010 Jan 15;327(5963):291-5. doi: 10.1126/science.1183021.
3
Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion.严重创伤后人类高迁移率族蛋白 B1 的早期释放：损伤严重程度和组织低灌注的作用。
Crit Care. 2009;13(6):R174. doi: 10.1186/cc8152. Epub 2009 Nov 4.
4
Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury.血小板减少和阿司匹林治疗可在输血相关急性肺损伤的双事件模型中保护小鼠。
J Clin Invest. 2009 Nov;119(11):3450-61. doi: 10.1172/JCI38432. Epub 2009 Oct 5.
5
Projections of global mortality and burden of disease from 2002 to 2030.2002年至2030年全球死亡率及疾病负担预测。
PLoS Med. 2006 Nov;3(11):e442. doi: 10.1371/journal.pmed.0030442.
6
Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage.新兴范式：Toll样受体4——组织损伤检测的前哨
Shock. 2006 Nov;26(5):430-7. doi: 10.1097/01.shk.0000228797.41044.08.
7
The origin and early evolution of mitochondria.线粒体的起源与早期演化
Genome Biol. 2001;2(6):REVIEWS1018. doi: 10.1186/gb-2001-2-6-reviews1018. Epub 2001 Jun 5.
8
The acute respiratory distress syndrome.急性呼吸窘迫综合征
N Engl J Med. 2000 May 4;342(18):1334-49. doi: 10.1056/NEJM200005043421806.
9
Postinjury multiple organ failure: a bimodal phenomenon.损伤后多器官功能衰竭：一种双峰现象。
J Trauma. 1996 Apr;40(4):501-10; discussion 510-2. doi: 10.1097/00005373-199604000-00001.
Zotero 插件