Am J Gastroenterol. 2010 Mar;105(3):621-3. doi: 10.1038/ajg.2009.720.
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Most patients with cryptogenic cirrhosis are considered to have had "burned out NAFLD." Although the recurrence and progression of NAFLD after liver transplantation (LT) have been shown previously, the incidence of de novo NAFLD after LT has not been extensively reported. In this issue of the American Journal of Gastroenterology, Dumortier et al. report the incidence of de novo post-LT NAFLD. Although most of the risk factors for post-LT NAFLD are similar to those for primary NAFLD, hepatic steatosis in the donor livers and a pre-transplant diagnosis of alcoholic liver disease remain independent risk factors. Although there are some limitations, this study provides the largest cohort of patients for whom post-LT NAFLD is reported.
非酒精性脂肪性肝病（NAFLD）是慢性肝病的常见病因。大多数隐源性肝硬化患者被认为患有“枯竭性 NAFLD”。尽管先前已经证明了肝移植（LT）后 NAFLD 的复发和进展，但 LT 后新发 NAFLD 的发生率尚未得到广泛报道。在本期《美国胃肠病学杂志》中，Dumortier 等人报告了 LT 后新发 NAFLD 的发生率。尽管 LT 后 NAFLD 的大多数危险因素与原发性 NAFLD 相似，但供体肝脏中的肝脂肪变性和移植前酒精性肝病的诊断仍然是独立的危险因素。尽管存在一些局限性，但本研究提供了最大的 LT 后 NAFLD 患者队列。
