Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006, Oviedo, Spain.
Org Biomol Chem. 2010 Mar 21;8(6):1431-7. doi: 10.1039/b925377g. Epub 2010 Jan 22.
Parallel interconnected kinetic asymmetric transformations were performed in order to obtain enantioenriched derivatives starting from a set of racemic or prochiral compounds. Thus, in a one-pot reaction using two redox biocatalysts (a BVMO and an ADH) and a catalytic amount of cofactor that acts as a mediator, enantioenriched ketones, sulfoxides, and sec-alcohols were concurrently obtained in a strict parallel way, minimising the quantity of reagents employed. By selecting the appropriate biocatalysts, this methodology represents a potential tool for performing stereodivergent transformations.
为了从一组外消旋或前手性化合物获得对映体富集的衍生物，进行了平行偶联的动力学不对称转化。因此，在一锅反应中使用两种氧化还原生物催化剂（BVMO 和 ADH）和少量作为介体的辅酶，可以以严格平行的方式同时获得对映体富集的酮、亚砜和仲醇，最大限度地减少试剂的用量。通过选择合适的生物催化剂，这种方法代表了进行立体发散转化的潜在工具。
