Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Semin Immunopathol. 2010 Jun;32(2):127-36. doi: 10.1007/s00281-010-0201-4. Epub 2010 Mar 4.
A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical negative modulator of TCR signaling encoded by the PTPN22 gene. The functional analysis of autoimmune-associated PTPN22 genetic variants suggests that genetic variability of TCR signal transduction contributes to the pathogenesis of autoimmunity in humans.
已知相当数量的蛋白酪氨酸磷酸酶（PTPs）可通过 T 细胞受体（TCR）调节信号转导。最近的人类遗传学研究表明，这些 PTPs 中的几个是由主要自身免疫基因编码的。在这里，我们将重点关注淋巴细胞酪氨酸磷酸酶（LYP），它是由 PTPN22 基因编码的 TCR 信号转导的关键负调节剂。与自身免疫相关的 PTPN22 遗传变异的功能分析表明，TCR 信号转导的遗传变异性有助于人类自身免疫的发病机制。
