Gastroenterology/ Hepatology Division, MetroHealth Medical Center, 2500 Metrohealth Drive, Cleveland, OH 44109, USA.
Metab Brain Dis. 2010 Mar;25(1):111-3. doi: 10.1007/s11011-010-9178-x. Epub 2010 Mar 5.
Until the advent of Liver transplantation, it was widely believed that Hepatic Encephalopathy (HE) was usually reversible. The exceptions were the so called "Acquired Hepatocerebral Degeneration cases" which were considered irreversible. Paradoxically, it seems, with liver transplantation, we have seen cases that contradict these rules. Whether the "residual effects" of HE, degenerative brain injury or independent neurological insults are causing post transplant neurological deficits is not easy to discern. As more emphasis is being put on maintaining brain 'status' after liver transplantation, we are finding confirmation of the largely reversible nature of HE. But, enough important exceptions to this rule are occurring to make further research on this topic mandatory.
在肝移植出现之前，人们普遍认为肝性脑病（HE）通常是可逆的。例外的是所谓的“获得性肝性脑变性病例”，被认为是不可逆转的。具有讽刺意味的是，随着肝移植的出现，我们已经看到了一些与这些规则相矛盾的病例。HE 的“残留效应”、退行性脑损伤还是独立的神经损伤导致移植后神经功能缺损，这并不容易辨别。由于人们越来越重视肝移植后保持大脑“状态”，我们发现HE 的很大程度上是可逆的这一性质得到了证实。但是，出现了足够多的重要例外情况，使得对这一课题进行进一步研究成为必要。
