Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico - Piazza G. Cesare, 11, 70124, Bari, Italy.
Department of Medicine, Section of Human Anatomy, University of Udine, Udine, Italy.
Clin Exp Med. 2021 Aug;21(3):355-360. doi: 10.1007/s10238-021-00688-x. Epub 2021 Feb 12.
Mast cells (MCs) are immune cells derived from myeloid lineage present in all classes of vertebrates and have emerged preceding much time the development of adaptive immunity. MCs are involved in inflammatory processes, allergic reactions, and host responses to parasites and bacteria infectious diseases. MCs are located at the host-environment interface, at many sites of initial antigen entry, including skin, lung and gastrointestinal tract, and have part of a protective mechanism. Skin has an important role in protecting the host from invasion both as physical barriers and by employing an intricate network of resident immune and non-immune cells include macrophages, T and B lymphocytes, MCs, neutrophils, eosinophils, and Langerhans cells. In this review we discussed the role of MCs in human skin cancers.
肥大细胞（MCs）是源自髓系的免疫细胞，存在于所有脊椎动物中，在适应性免疫发展之前就已经出现。MCs 参与炎症过程、过敏反应以及宿主对寄生虫和细菌感染性疾病的反应。MCs 位于宿主-环境界面，位于初始抗原进入的许多部位，包括皮肤、肺和胃肠道，并构成一部分保护机制。皮肤作为物理屏障，并通过利用驻留免疫和非免疫细胞的复杂网络，包括巨噬细胞、T 和 B 淋巴细胞、MCs、中性粒细胞、嗜酸性粒细胞和朗格汉斯细胞，在保护宿主免受入侵方面发挥着重要作用。在这篇综述中，我们讨论了 MCs 在人类皮肤癌中的作用。
