Pediatric Heart Lung Center, The Children's Hospital, B395, 13123 E. 16th Avenue, Aurora, CO, 80045, USA.
Adv Exp Med Biol. 2010;661:323-35. doi: 10.1007/978-1-60761-500-2_21.
Abstract Of diverse growth factors that contribute to normal lung development, vascular endothelial growth factor (VEGF) plays an especially prominent role in the normal growth and development of the pulmonary circulation in the fetus and newborn. Strong experimental and clinical data support the role of impaired VEGF signaling in the pathogenesis of two major clinical disorders of the developing lung circulation: persistent pulmonary hypertension of the newborn (PPHN) and bronchopulmonary dysplasia (BPD). These disorders are each characterized by impaired vascular growth, structure and reactivity, which are at least partly due to endothelial cell dysfunction. This chapter will briefly discuss VEGF signaling during normal lung development and how disruption of VEGF signaling contribute to the pathogenesis of neonatal pulmonary vascular disease in these settings.
多种生长因子有助于肺的正常发育，其中血管内皮生长因子（VEGF）在胎儿和新生儿肺循环的正常生长和发育中起着尤为突出的作用。强有力的实验和临床数据支持 VEGF 信号受损在两种主要的发育中肺循环疾病的发病机制中的作用：新生儿持续性肺动脉高压（PPHN）和支气管肺发育不良（BPD）。这些疾病的特点是血管生长、结构和反应性受损，至少部分是由于内皮细胞功能障碍。本章将简要讨论 VEGF 信号在正常肺发育过程中的作用，以及 VEGF 信号的破坏如何导致这些情况下新生儿肺血管疾病的发病机制。
