Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
Adv Exp Med Biol. 2010;662:121-6. doi: 10.1007/978-1-4419-1241-1_17.
It is not clear whether blood hemoglobin concentration ([Hb]) increases with an increase in the exposure period of intermittent hypoxia (IHx) and reaches a constant level. Furthermore, it is not known whether plasma erythropoietin concentration ([EPO]) also increases with an increase in the exposure period. Using a rat model, first, we evaluated changes in [EPO] every hour after single exposure of 10% O(2) for 120 min in order to determine a peak level of [EPO]. Second, we evaluated the effect of IHx of 10% O(2), 120 min/day for 0 (control), 1, 2, 3, 4, 6 and 8 weeks on [Hb], arterial blood pressure (BP), heart rate (HR), arterial blood gases (ABGs) and [EPO]. [EPO] increased after cessation of the single hypoxic exposure, reached a peak at 1 h, and decreased gradually to the control levels within 18 h. IHx of 10% O(2), 120 min/day, produced a time-dependent increase in [Hb], and [Hb] reached a constant level after the exposure for 6 weeks. BP increased after the exposure for 4 weeks and remained elevated. There was no significant difference in HR and ABGs. [EPO] increased significantly and remained elevated at the same level for 1-3 weeks, however, the peak level of [EPO] declined markedly after [Hb] reached a constant level.
血红蛋白浓度（[Hb]）是否随间歇性低氧（IHx）暴露期的增加而增加，并达到稳定水平尚不清楚。此外，尚不清楚血浆促红细胞生成素浓度（[EPO]）是否也随暴露期的增加而增加。使用大鼠模型，首先，我们评估了单次 10% O2 暴露 120 分钟后每小时[EPO]的变化，以确定[EPO]的峰值水平。其次，我们评估了 10% O2、120 分钟/天的 IHx 对[Hb]、动脉血压（BP）、心率（HR）、动脉血气（ABGs）和[EPO]的影响。在单次低氧暴露停止后，[EPO]增加，在 1 小时达到峰值，然后在 18 小时内逐渐降至对照水平。10% O2、120 分钟/天的 IHx 导致[Hb]呈时间依赖性增加，暴露 6 周后[Hb]达到稳定水平。BP 在暴露 4 周后升高，并且保持升高。HR 和 ABGs 没有显著差异。[EPO]显著增加并在 1-3 周内保持升高水平，但在[Hb]达到稳定水平后，[EPO]的峰值水平显著下降。
