Department of Neurosurgery, Nihon University School of Medicine, Tokyo, Japan.
Adv Exp Med Biol. 2010;662:525-30. doi: 10.1007/978-1-4419-1241-1_76.
We demonstrated that ischemic strokes exhibit an increase of deoxyhemoglobin during activation. We evaluated the effect of revascu-larization on the abnormal evoked cerebral blood oxygenation (CBO) re-sponses in these patients, employing near-infrared spectroscopy (NIRS). We selected five patients who exhibited an increase of deoxyhemoglobin associated with increases of oxyhemoglobin and total hemoglobin during activation for this study. These patients showed marked reductions of base-line regional cerebral blood flow and cerebrovascular reserve capacity, which were improved 1 week after revascularization. Postoperative NIRS demonstrated that the increase of deoxyhemoglobin during activa-tion was not observed after revascularization. This preliminary study demonstrated that the abnormal evoked-CBO response in ischemic stroke patients could be improved by revascularization.
我们证明了在激活期间，缺血性中风表现出脱氧血红蛋白的增加。我们使用近红外光谱（NIRS）评估了再灌注对这些患者异常诱发脑血氧（CBO）反应的影响。我们选择了 5 名在激活过程中表现出脱氧血红蛋白增加的患者进行本研究，同时伴有氧合血红蛋白和总血红蛋白的增加。这些患者表现出明显的基线区域脑血流和脑血管储备能力降低，再灌注治疗 1 周后得到改善。术后 NIRS 显示，再灌注后激活期间脱氧血红蛋白的增加未被观察到。这项初步研究表明，再灌注可以改善缺血性中风患者的异常诱发-CBO 反应。
