Santosham M, Goepp J, Burns B, Reid R, O'Donovan C, Pathak R, Sack R B
Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.
Pediatrics. 1991 May;87(5):619-22.
The introduction of a soy-based, lactose-free formula during the acute phase of diarrheal illness in infants has been shown to reduce stool output and duration of diarrhea in hospitalized patients. In the United States, most infants with acute diarrhea are treated as outpatients. In the present study, infants with diarrhea who were treated as outpatients were randomly assigned to receive either a soy-based, lactose-free formula alternating with oral rehydration solution from the beginning of therapy ("early feeding") or oral rehydration solution alone for the first 24 hours of therapy, followed by a soy-based, lactose-free formula alternating with oral rehydration solution (control group). Twenty-nine infants were randomly assigned to the early-feeding group and 27 to the control group. Twenty-one (72%) of 29 in the early-feeding group resolved their diarrhea at the end of 48 hours of therapy compared with 12 (44%) of 27 in the group fed oral rehydration solution only (P = .02). It is concluded that the introduction of a soy-based, lactose-free formula from the beginning of therapy for acute diarrhea in children treated as outpatients is safe and may shorten duration of diarrhea while maintaining adequate caloric intake.
在婴儿腹泻疾病急性期引入以大豆为基础的无乳糖配方奶粉，已被证明可减少住院患者的粪便排出量并缩短腹泻持续时间。在美国，大多数急性腹泻婴儿作为门诊患者接受治疗。在本研究中，作为门诊患者接受治疗的腹泻婴儿被随机分配，从治疗开始时起要么接受以大豆为基础的无乳糖配方奶粉与口服补液盐交替使用（“早期喂养”），要么在治疗的前24小时仅接受口服补液盐，随后接受以大豆为基础的无乳糖配方奶粉与口服补液盐交替使用（对照组）。29名婴儿被随机分配到早期喂养组，27名被分配到对照组。早期喂养组29名婴儿中有21名（72%）在治疗48小时结束时腹泻症状缓解，而仅接受口服补液盐喂养组27名婴儿中有12名（44%）腹泻症状缓解（P = 0.02）。得出的结论是，对于作为门诊患者治疗的儿童急性腹泻，从治疗开始就引入以大豆为基础的无乳糖配方奶粉是安全的，并且可能在维持足够热量摄入的同时缩短腹泻持续时间。
