Xu Jia-Hua, Huang Ying
Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai 201102, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2009 Jul;11(7):532-6.
To study the efficiency of lactose-free formula feeding as an adjunctive therapy in infants with acute diarrhea.
A rigorous double-blind, randomized, controlled equivalence trial was performed. One hundred and twenty infants with acute diarrhea were randomly divided into two groups: lactose-free formula and conventional formula feeding. The two groups were given conventional medical treatment and oral rehydration therapy. The therapeutic effects were observed 1 week after treatment.
The cure rate and the total effective rate were 58.3% and 96.7% respectively in the lactose-free formula group, and they were 8.3% and 85.0% respectively in the conventional formula group. There were significant differences in the therapeutic effect between the two groups (p<0.05). The duration of diarrhea remission (3.17+/-1.04 days) in the lactose-free formula group was significantly shorter than that in the conventional formula group (5.25+/-1.58 days) (p<0.05). After treatment the incidence of fecal flora disturbance was lower in the lactose-free formula group than that in the conventional formula group (p<0.05). No aderverse events were observed in the two groups.
Lactose-free formula feeding together with conventional therapy can significantly shorten the disease course and improve the treatment outcome in infants with acute diarrhea.
研究无乳糖配方奶喂养作为辅助治疗对急性腹泻婴儿的疗效。
进行了一项严格的双盲、随机、对照等效性试验。120例急性腹泻婴儿被随机分为两组：无乳糖配方奶组和传统配方奶喂养组。两组均给予常规药物治疗和口服补液治疗。治疗1周后观察疗效。
无乳糖配方奶组的治愈率和总有效率分别为58.3%和96.7%，传统配方奶组分别为8.3%和85.0%。两组疗效差异有统计学意义（p<0.05）。无乳糖配方奶组腹泻缓解持续时间（3.17±1.04天）明显短于传统配方奶组（5.25±1.58天）（p<0.05）。治疗后，无乳糖配方奶组粪便菌群紊乱发生率低于传统配方奶组（p<0.05）。两组均未观察到不良事件。
无乳糖配方奶喂养联合传统疗法可显著缩短急性腹泻婴儿的病程，提高治疗效果。
