Santosham M, Foster S, Reid R, Bertrando R, Yolken R, Burns B, Sack R B
Pediatrics. 1985 Aug;76(2):292-8.
A controlled study was conducted comparing the standard method of treating hospitalized infants with acute diarrhea (limited starvation) with the initiation of "early feeding" using a soy-based, lactose-free formula in infants of an American Indian tribe 12 months of age or younger. Forty-three patients, randomly assigned to group A, were given a soy-based, lactose-free formula four hours after hospitalization, and 44 patients, randomly assigned to group B, received standard therapy (food was withheld for the first 48 hours of hospitalization). After the first 48 hours, the same soy-based, lactose-free formula was given to the group B patients. Fluid intake and output of stool, urine, and vomitus were measured until the diarrhea resolved. Overall, group A patients showed less mean stool output (121 +/- 129 (SD) mL/kg) than group B patients (299 +/- 319 mL/kg) (P less than .001). Furthermore, the duration of illness was significantly shorter in group A patients (54 +/- 28 hours v 93 +/- 56 hours) (P less than .001). It was concluded that soy-based, lactose-free formulas can be safely used during the acute phase of diarrheal illness in infants and that their use shortens the duration of illness and decreases stool output in comparison with standard therapy.
进行了一项对照研究，比较了治疗住院急性腹泻婴儿的标准方法（有限饥饿法）与对12个月及以下美国印第安部落婴儿采用基于大豆的无乳糖配方奶进行“早期喂养”的方法。43名随机分配到A组的患者在住院4小时后给予基于大豆的无乳糖配方奶，44名随机分配到B组的患者接受标准治疗（住院的前48小时不提供食物）。48小时后，给B组患者同样的基于大豆的无乳糖配方奶。测量液体摄入量以及粪便、尿液和呕吐物的排出量，直至腹泻缓解。总体而言，A组患者的平均粪便排出量（121±129（标准差）mL/kg）低于B组患者（299±319 mL/kg）（P<0.001）。此外，A组患者的病程明显更短（54±28小时对93±56小时）（P<0.001）。得出的结论是，基于大豆的无乳糖配方奶可在婴儿腹泻病急性期安全使用，与标准治疗相比，其使用可缩短病程并减少粪便排出量。
