阿尔茨海默病的新型疗法：最新进展
Novel therapeutics for Alzheimer's disease: an update.
作者信息
Bonda David J, Lee Hyun-Pil, Lee Hyoung-gon, Friedlich Avi L, Perry George, Zhu Xiongwei, Smith Mark A
机构信息
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
Curr Opin Drug Discov Devel. 2010 Mar;13(2):235-46.
Abstract
As the most prevalent form of dementia worldwide, Alzheimer's disease (AD) continues to be a burden for patients and their families. In addition, with the global population of aged individuals increasing exponentially, AD represents a significant economic burden to society. The development of an effective approach for the treatment of AD is thus of major importance, as current treatment strategies are limited to agents that attenuate disease symptomatology without addressing the causes of disease. A considerable need exists for the development of an effective therapy to prevent, or at least delay, the progression of AD. Current hypotheses for the pathogenesis of AD are discussed in this review, with a particular emphasis on the implications of these hypotheses with respect to treatment strategies and preventive measures.
摘要
作为全球最常见的痴呆形式，阿尔茨海默病（AD）仍然是患者及其家庭的负担。此外，随着全球老年人口呈指数级增长，AD给社会带来了巨大的经济负担。因此，开发一种有效的AD治疗方法至关重要，因为目前的治疗策略仅限于减轻疾病症状的药物，而没有解决疾病的病因。迫切需要开发一种有效的疗法来预防或至少延缓AD的进展。本综述讨论了目前关于AD发病机制的假说，特别强调了这些假说对治疗策略和预防措施的影响。
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