Su Bo, Wang Xinglong, Zheng Ling, Perry George, Smith Mark A, Zhu Xiongwei
Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA.
Biochim Biophys Acta. 2010 Jan;1802(1):135-42. doi: 10.1016/j.bbadis.2009.09.013. Epub 2009 Sep 30.
Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases. A deeper understanding of the remarkably dynamic nature of mitochondria, characterized by a delicate balance of fission and fusion, has helped to fertilize a recent wave of new studies demonstrating abnormal mitochondrial dynamics in neurodegenerative diseases. This review highlights mitochondrial dysfunction and abnormal mitochondrial dynamics in Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and Huntington disease and discusses how these abnormal mitochondrial dynamics may contribute to mitochondrial and neuronal dysfunction. We propose that abnormal mitochondrial dynamics represents a key common pathway that mediates or amplifies mitochondrial dysfunction and neuronal dysfunction during the course of neurodegeneration.
线粒体功能障碍是各种神经退行性疾病的一个显著特征。对线粒体显著动态特性（其特点是裂变与融合之间的微妙平衡）的更深入理解，有助于推动最近一波新研究，这些研究表明神经退行性疾病中线粒体动态存在异常。本综述重点介绍了阿尔茨海默病、帕金森病、肌萎缩侧索硬化症和亨廷顿病中的线粒体功能障碍和线粒体动态异常，并讨论了这些异常的线粒体动态如何导致线粒体和神经元功能障碍。我们认为，异常的线粒体动态代表了一条关键的共同途径，在神经退行性变过程中介导或放大线粒体功能障碍和神经元功能障碍。
