Department of Endocrinology and Diabetology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
Endokrynol Pol. 2010 Jan-Feb;61(1):7-12.
The growth of a tumour is limited by its neovascularisation. Angiogenesis is dependent on a dynamic balance between its activators and inhibitors. One of the most important antiangiogenic factors is endostatin. The aim of the study was to assess the usefulness of serum endostatin levels as a potential marker of metastases of well-differentiated thyroid cancer, and to estimate the effect of endogenous TSH stimulation on serum endostatin levels.
The study group consisted of 68 patients with differentiated thyroid cancer. We provided a cross-sectional analysis of the study group divided into patients with distant and/or locoregional metastases and patients with remission, and compared it with serum endostatin levels of healthy volunteers. Serum endostatin concentration was measured by ELISA kits (R & D Systems).
Median endostatin concentration was significantly higher in patients with distant metastases than in patients with remission (141.95 v. 105.345 ng/ml, p < 0.05). This was not observed in patients with locoregional metastases. Serum endostatin levels were significantly higher in the study group, including patients with remission, than in the control group of healthy volunteers (remission v. healthy median 105.3 v. 88.1 ng/ml, p < 0.05). During endogenous TSH stimulation, endostatin levels significantly decreased (122.94 v. 93.60 ng/ml, p < 0.05).
The study indicates that endogenous TSH stimulation plays a role in the regulation of endostatin secretion. Although median serum endostatin levels are higher in patients with distant metastases than in patients with remission, its clinical usefulness is limited due to the overlapping data between the study groups. (Pol J Endocrinol 2010; 61 (1): 7-12).
肿瘤的生长受到其新生血管形成的限制。血管生成依赖于其激活剂和抑制剂之间的动态平衡。最重要的抗血管生成因子之一是内皮抑素。本研究的目的是评估血清内皮抑素水平作为分化型甲状腺癌转移的潜在标志物的有用性，并估计内源性 TSH 刺激对血清内皮抑素水平的影响。
研究组由 68 例分化型甲状腺癌患者组成。我们对研究组进行了横断面分析，分为远处和/或局部转移患者和缓解患者，并与健康志愿者的血清内皮抑素水平进行了比较。采用 ELISA 试剂盒（R & D Systems）测定血清内皮抑素浓度。
远处转移患者的中位内皮抑素浓度明显高于缓解患者（141.95 v. 105.345 ng/ml，p < 0.05）。在局部转移患者中未观察到这种情况。包括缓解患者在内的研究组血清内皮抑素水平明显高于健康志愿者对照组（缓解 v. 健康中位数 105.3 v. 88.1 ng/ml，p < 0.05）。在内源性 TSH 刺激期间，内皮抑素水平显著降低（122.94 v. 93.60 ng/ml，p < 0.05）。
本研究表明内源性 TSH 刺激在调节内皮抑素分泌中起作用。尽管远处转移患者的中位血清内皮抑素水平高于缓解患者，但由于研究组之间的数据重叠，其临床应用受到限制。（波兰内分泌杂志 2010；61（1）：7-12）。
