Institute of Biomedicine, University of Helsinki, Pharmacology, PO Box 63, FI-00014 Helsinki, Finland.
World J Gastroenterol. 2010 Mar 7;16(9):1057-62. doi: 10.3748/wjg.v16.i9.1057.
Independent of the cause and location, inflammation - even when minimal - has clear effects on gastrointestinal morphology and function. These result in altered digestion, absorption and barrier function. There is evidence of reduced villus height and crypt depth, increased permeability, as well as altered sugar and peptide absorption in the small intestine after induction of inflammation in experimental models, which is supported by some clinical data. Identification of inflammatory factors which may promote the process of gastrointestinal dysfunction as well as clinical research to verify experimental observations of inflammatory modulation of gastrointestinal function are required. Moreover, nutritional strategies to support functional restitution are needed.
无论病因和部位如何，炎症 - 即使是轻微的炎症 - 都会对胃肠道形态和功能产生明显影响。这些变化导致消化、吸收和屏障功能改变。有证据表明，在实验模型中诱导炎症后，小肠的绒毛高度和隐窝深度降低，通透性增加，以及糖和肽吸收改变，一些临床数据也支持这一点。需要确定可能促进胃肠道功能障碍过程的炎症因子，并进行临床研究以验证炎症对胃肠道功能的调节作用。此外，还需要营养策略来支持功能恢复。
