Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
World J Gastroenterol. 2010 Mar 7;16(9):1110-4. doi: 10.3748/wjg.v16.i9.1110.
To examine the feasibility of predicting the flare-up of ulcerative colitis (UC) before symptoms emerge using the immunochemical fecal occult blood test (I-FOBT).
We prospectively measured fecal hemoglobin concentrations in 78 UC patients using the I-FOBT every 1 or 2 mo.
During a 20 mo-period, 823 fecal samples from 78 patients were submitted. The median concentration of fecal hemoglobin was 41 ng/mL (range: 0-392 500 ng/mL). There were three types of patients with regard to the correlation between I-FOBT and patient symptoms; the synchronous transition type with symptoms (44 patients), the unrelated type with symptoms (19 patients), and the flare-up predictive type (15 patients). In patients with the flare-up predictive type, the values of I-FOBT were generally low during the study period with stable symptoms. Two to four weeks before the flare-up of symptoms, the I-FOBT values were high. Thus, in these patients, I-FOBT could predict the flare-up before symptoms emerged.
Flare-up could be predicted by I-FOBT in approximately 20% of UC patients. These results warrant periodical I-FOBT in UC patients.
探讨使用免疫化学粪便隐血试验（I-FOBT）在症状出现前预测溃疡性结肠炎（UC）发作的可行性。
我们前瞻性地使用 I-FOBT 每 1 或 2 个月测量 78 例 UC 患者的粪便血红蛋白浓度。
在 20 个月的时间内，78 名患者共提交了 823 份粪便样本。粪便血红蛋白的中位数浓度为 41ng/mL（范围：0-392500ng/mL）。根据 I-FOBT 与患者症状之间的相关性，患者可分为三种类型；与症状同步转变型（44 例）、与症状无关型（19 例）和发作预测型（15 例）。在发作预测型患者中，研究期间 I-FOBT 的值通常较低，症状稳定。在症状发作前 2 至 4 周，I-FOBT 值较高。因此，在这些患者中，I-FOBT 可以预测症状出现前的发作。
约 20%的 UC 患者可通过 I-FOBT 预测发作。这些结果提示 UC 患者需要定期进行 I-FOBT。
