Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Org Lett. 2010 Apr 2;12(7):1524-7. doi: 10.1021/ol100249v.
Two new omega-phenyl polyketide peroxides, plakinic acids K and L, were isolated from a two-sponge association of Plakortis halichondroides and Xestospongia deweerdtae. The absolute configurations of the remote dimethyl-branched stereocenters in plakinic acid K were assigned by degradation of plakinic acid K to a long-chain naphthamide and analysis by liposomal circular dichroism (L-CD) and comparison with synthetic standards.
两种新的 ω- 苯基聚酮过氧化物,即 plakinic 酸 K 和 L,从 Plakortis halichondroides 和 Xestospongia deweerdtae 的双海绵共生体中分离得到。通过将 plakinic 酸 K 降解为长链萘酰胺,并通过脂质体圆二色性(L-CD)分析和与合成标准品进行比较,确定了 plakinic 酸 K 中远程二甲基支化手性中心的绝对构型。