来自海绵物种Plakinastrella的三种新过氧化物。

Three new peroxides from the sponge Plakinastrella species.

作者信息

Chen Y, Killday K B, McCarthy P J, Schimoler R, Chilson K, Selitrennikoff C, Pomponi S A, Wright A E

机构信息

Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, Florida 34946, USA.

出版信息

J Nat Prod. 2001 Feb;64(2):262-4. doi: 10.1021/np000368+.

DOI:10.1021/np000368+

PMID:11430018

Abstract

Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide-lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 micrograms/mL (SDB) and 3.1 micrograms/mL (RPMI) for 3, and 25 micrograms/mL (SDB) and 6.25 micrograms/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 micrograms/mL.

摘要

从塞舌尔费利西泰岛采集的扁海绵属海绵中分离出两种新的五元环过氧酸，普拉金酸F（3）和表普拉金酸F（4），以及一种新的过氧内酯，普拉科尔内酯F（5）。通过光谱分析阐明了其结构。游离酸3和4对白色念珠菌表现出中等抗真菌活性，3的最小抑菌浓度分别为25微克/毫升（SDB）和3.1微克/毫升（RPMI），4的最小抑菌浓度分别为25微克/毫升（SDB）和6.25微克/毫升（RPMI）。两者对烟曲霉也表现出中等的体外抑制作用，IC90为25微克/毫升。