Deng Gary, Davatgarzadeh Arousha, Yeung Simon, Cassileth Barrie
J Soc Integr Oncol. 2010 Winter;8(1):20-30.
There are important safety concerns associated with dietary supplements and foods rich in phytoestrogens, especially for breast cancer patients with hormone-sensitive disease. However, no consensus has been reached concerning specific dietary items that should be avoided, and safe levels of potentially problematic foods have yet to be determined. Excellent qualitative reviews of phytoestrogens and breast cancer have been published. These list agents that contain phytoestrogens and offer general cautions. Quantitative reviews, however, are needed but not yet available. Here we review quantitative data on phytoestrogens, their interaction with estrogen receptors, their bioavailability and pharmacokinetics, and their effects on breast cancer cells and animal models. We also note foods and botanicals with substances that interact with estrogen receptors and discuss the phytoestrogens they contain. Based on current evidence, we propose recommendations for advising breast cancer patients, which may also serve as a basis for the development of clinical practice guidelines.
膳食补充剂和富含植物雌激素的食物存在重要的安全问题，尤其是对于患有激素敏感性疾病的乳腺癌患者。然而，对于应避免的特定饮食项目尚未达成共识，潜在问题食物的安全水平也尚未确定。关于植物雌激素与乳腺癌的优秀定性综述已经发表。这些综述列出了含有植物雌激素的物质并给出了一般注意事项。然而，定量综述是需要的，但目前尚未可得。在此，我们综述了关于植物雌激素的定量数据、它们与雌激素受体的相互作用、它们的生物利用度和药代动力学，以及它们对乳腺癌细胞和动物模型的影响。我们还指出了含有与雌激素受体相互作用物质的食物和植物，并讨论它们所含的植物雌激素。基于当前证据，我们提出针对乳腺癌患者的建议，这些建议也可作为制定临床实践指南的基础。
