Department of Surgery - Surgical Oncology, Michael E. DeBakey VA Medical Center, Houston, TX, United States.
Crit Rev Oncol Hematol. 2011 Feb;77(2):100-8. doi: 10.1016/j.critrevonc.2010.02.003. Epub 2010 Mar 4.
Aging of the population - global graying - is occurring rapidly, with significant effects on epidemiology, treatment and outcomes for cancer patients. In colorectal cancer, outcomes for the elderly are worse than those for younger patients, partially driven by treatment disparities between the two groups. Nonetheless, standard-of-care treatment for the elderly results in equivalent long-term outcomes to those observed in the younger population; and available data support the use of aggressive surgery and adjuvant therapies in well-selected patients. Data evaluating epidemiology, treatment patterns and outcomes in elderly patients with colorectal cancer liver metastasis are lacking. Liver resection offers the only curative approach, but it is rarely offered to older adults. Current data support the use of hepatectomy for well-selected elderly colorectal cancer patients with liver metastasis; however, this and other evolving therapies need to be assessed in the elderly to better define their role, indications, safety and outcomes.
人口老龄化——全球老龄化——正在迅速发生，对癌症患者的流行病学、治疗和结果产生重大影响。在结直肠癌中，老年人的预后比年轻患者差，部分原因是两组之间的治疗差异。尽管如此，老年人的标准治疗结果与年轻人群观察到的结果相当；并且现有数据支持在精选患者中使用积极的手术和辅助治疗。缺乏关于老年结直肠癌肝转移患者的流行病学、治疗模式和结果的评估数据。肝切除术是唯一的治愈方法，但很少提供给老年人。目前的数据支持对有肝转移的老年结直肠癌患者进行肝切除术；然而，需要在老年人中评估这种治疗方法和其他正在发展的治疗方法，以更好地确定其作用、适应证、安全性和结果。
