Suppr超能文献

青春期启动的神经内分泌干扰以及生殖稳态和能量平衡之间的相互作用。

Neuroendocrine disruption of pubertal timing and interactions between homeostasis of reproduction and energy balance.

机构信息

Developmental Neuroendocrinology Unit, GIGA Neurosciences, University of Liège and Department of Pediatrics, CHU de Liège, Belgium.

出版信息

Mol Cell Endocrinol. 2010 Aug 5;324(1-2):110-20. doi: 10.1016/j.mce.2010.02.033. Epub 2010 Mar 4.

Abstract

The involvement of environmental factors such as endocrine disrupting chemicals (EDCs) in the timing of onset of puberty is suggested by recent changes in age at onset of puberty and pattern of distribution that are variable among countries, as well as new forms of sexual precocity after migration. However, the evidence of association between early or late pubertal timing and exposure to EDCs is weak in humans, possibly due to heterogeneity of effects likely involving mixtures and incapacity to assess fetal or neonatal exposure retrospectively. The neuroendocrine system which is crucial for physiological onset of puberty is targeted by EDCs. These compounds also act directly in the gonads and peripheral sex-steroid sensitive tissues. Feedbacks add to the complexity of regulation so that changes in pubertal timing caused by EDCs can involve both central and peripheral mechanisms. In experimental conditions, several neuroendocrine endpoints are affected by EDCs though only few studies including from our laboratory aimed at EDC involvement in the pathophysiology of early sexual maturation. Recent observations support the concept that EDC cause disturbed energy balance and account for the obesity epidemic. Several aspects are linking this system and the reproductive axis: coexisting neuroendocrine and peripheral effects, dependency on fetal/neonatal programming and the many factors cross-linking the two systems, for instance leptin, adiponectin, Agouti Related Peptide (AgRP). This opens perspectives for future research and, hopefully, measures preventing the disturbances of homeostasis caused by EDCs.

摘要

环境因素(如内分泌干扰物)在青春期发病时间中的作用,可由青春期发病年龄和分布模式的近期变化得到提示,这些变化在不同国家之间存在差异,并且在移民后出现了新形式的性早熟。然而,人类中青春期提前或推迟与接触内分泌干扰物之间的关联证据较弱,这可能是由于作用的异质性,可能涉及混合物,并且无法回顾性评估胎儿或新生儿的暴露情况。内分泌干扰物针对的是对青春期生理发生至关重要的神经内分泌系统。这些化合物还直接作用于性腺和外周性类固醇敏感组织。反馈增加了调节的复杂性,因此内分泌干扰物引起的青春期时间变化可能涉及中枢和外周机制。在实验条件下,尽管我们实验室的少数研究旨在探讨内分泌干扰物在性早熟发病机制中的作用,但已有多项研究表明内分泌干扰物会影响多种神经内分泌终点。最近的观察结果支持这样一种观点,即内分泌干扰物会导致能量平衡紊乱,并导致肥胖流行。该系统和生殖轴有几个方面相互关联:共存的神经内分泌和外周作用、对胎儿/新生儿编程的依赖性以及将两个系统相互联系的许多因素,例如瘦素、脂联素、Agouti 相关肽(AgRP)。这为未来的研究开辟了前景,并有望采取措施防止内分泌干扰物引起的体内平衡紊乱。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验