Pediatric Endocrinology, CHU Liège, 600, rue de Gaillarmont, B-4032, Chênée, Belgium.
Neuroendocrinology Unit, GIGA Neurosciences, University of Liège, Quartier Hôpital, Tour 4 - 1er étage, 15 Avenue Hippocrate, B-4000, Liège, Belgium.
Environ Health. 2018 Apr 23;17(1):42. doi: 10.1186/s12940-018-0385-y.
The regulatory management of chemicals and toxicants in the EU addresses hundreds of different chemicals and health hazards individually, one by one. An issue is that, so far, the possible interactions among chemicals or hazards are not considered as such. Another issue is the anticipated delay of several decades before effective protection of public health by regulatory decisions due to a time consuming process. Prenatal and early postnatal life is highly vulnerable to environmental health hazards with lifelong consequences, and a priority period for reduction of exposure. There are some initiatives regarding recommendations for pregnant women aiming at protection against one or another category of health hazard, however not validated by intervention studies.
Here, we aim at strengthening the management of exposure to individual health hazards during pregnancy and lactation, with protective measures in a global strategy of Environmental Hygiene. We hypothesize that such a strategy could reduce both the individual effects of harmful agents in complex mixtures and the possible interactions among them. A panel of experts should develop and endorse implementable measures towards a protective behavior. Their application is meant to be preferably as a package of measures in order to maximize protection and minimize interactions in causing adverse effects. Testing our hypothesis requires biomonitoring studies and longitudinal evaluation of health endpoints in the offspring. Favorable effects would legitimate further action towards equal opportunity access to improved environmental health.
Environmental Hygiene is proposed as a global strategy aiming at effective protection of pregnant women, unborn children and infants against lifelong consequences of exposure to combinations of adverse lifestyle factors.
欧盟对化学品和有毒物质的监管管理分别针对数百种不同的化学品和健康危害因素进行逐一管理。目前存在的一个问题是，尚未考虑到这些化学品或危害因素之间可能存在的相互作用。另一个问题是，由于监管决策过程耗时冗长，预计要在几十年后才能有效保护公众健康。产前和产后早期生命极易受到环境健康危害因素的影响，从而带来终身影响，这是减少接触的优先时期。虽然有一些针对孕妇的建议举措，旨在保护其免受某一类健康危害因素的影响，但这些建议尚未得到干预研究的验证。
在此，我们旨在加强对孕妇和哺乳期接触个别健康危害因素的管理，并在环境卫生综合策略中采取保护措施。我们假设，这样的策略可以降低复杂混合物中有害剂的个体效应，以及它们之间可能存在的相互作用。一个专家小组应制定并认可可实施的措施，以实现保护行为。其应用最好是作为一整套措施，以最大限度地保护和减少引起不良影响的相互作用。要验证我们的假设，需要进行生物监测研究，并对后代的健康终点进行纵向评估。有利的影响将使我们有理由采取进一步行动，为改善环境卫生提供平等机会。
环境卫生被提议作为一种全球策略，旨在有效保护孕妇、未出生的儿童和婴儿，使其免受接触不良生活方式因素组合带来的终身影响。
