Department of Obstetrics and Gynecology, Hôpital Ste-Justine, Université de Montréal, Montreal, QC, Canada.
Am J Obstet Gynecol. 2010 Mar;202(3):239.e1-239.e10. doi: 10.1016/j.ajog.2010.01.050.
We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women.
In a multicenter randomized controlled trial, women were stratified by the risk status and assigned to daily treatment (1 g vitamin C and 400 IU vitamin E) or placebo. The primary outcome was GH and its adverse conditions.
Of the 2647 women randomized, 2363 were included in the analysis. There was no difference in the risk of GH and its adverse conditions between groups (relative risk, 0.99; 95% confidence interval, 0.78-1.26). However, vitamins C and E increased the risk of fetal loss or perinatal death (nonprespecified) as well as preterm prelabor rupture of membranes.
Vitamin C and E supplementation did not reduce the rate of preeclampsia or GH, but increased the risk of fetal loss or perinatal death and preterm prelabor rupture of membranes.
本研究旨在探讨产前补充维生素 C 和维生素 E 是否能降低高危和低危孕妇发生妊娠高血压（GH）及其不良结局的风险。
采用多中心随机对照试验，根据风险状况对孕妇进行分层，并随机分配至每日治疗组（1 g 维生素 C 和 400 IU 维生素 E）或安慰剂组。主要结局为 GH 及其不良结局。
在 2647 名随机分配的孕妇中，2363 名孕妇纳入分析。两组 GH 及其不良结局的风险无差异（相对风险，0.99；95%置信区间，0.78-1.26）。然而，维生素 C 和 E 增加了胎儿丢失或围产儿死亡（非预设）以及早产胎膜早破的风险。
维生素 C 和 E 补充剂并未降低子痫前期或 GH 的发生率，但增加了胎儿丢失或围产儿死亡以及早产胎膜早破的风险。
