Bull A W, Earles S M, Bronstein J C
Department of Chemistry, Oakland University, Rochester, MI 48309.
Prostaglandins. 1991 Jan;41(1):43-50. doi: 10.1016/0090-6980(91)90103-m.
Oxidation products of linoleic acid, including hydroperoxy- and hydroxyoctadecadienoic acids have been shown to possess biological activities in a number of different systems. In this work we describe an enzymatic activity which catalyzes the conversion of 13-hydroxyoctadecadienoic acid to a 2,4-dienone product, 13-oxooctadecadienoic acid. The enzyme activity is widely distributed, with the highest activity in the colon and the liver. The distribution of activity among various tissues is distinct from other dehydrogenases known to use oxygenated unsaturated fatty acids as substrates. This enzyme may play a key role in the metabolism of 13-hydroxyoctadecadienoic acid in epithelial tissues.
亚油酸的氧化产物，包括氢过氧和羟基十八碳二烯酸，已被证明在许多不同系统中具有生物活性。在这项工作中，我们描述了一种酶活性，它催化13-羟基十八碳二烯酸转化为一种2,4-二烯酮产物，即13-氧代十八碳二烯酸。这种酶活性分布广泛，在结肠和肝脏中活性最高。其活性在各种组织中的分布与已知以氧化的不饱和脂肪酸为底物的其他脱氢酶不同。这种酶可能在上皮组织中13-羟基十八碳二烯酸的代谢中起关键作用。
