Faculty of Tropical Medicine, Mahidol University, Bangkok,
Am J Trop Med Hyg. 2010 Mar;82(3):368-70. doi: 10.4269/ajtmh.2010.09-0233.
Scrub typhus is transmitted by trombiculid mites and is endemic to East and Southeast Asia and Northern Australia. The clinical syndrome classically consists of a fever, rash, and eschar, but scrub typhus also commonly presents as an undifferentiated fever that requires laboratory confirmation of the diagnosis, usually by indirect fluorescent antibody (IFA) assay. We discuss the limitations of IFA, debate the value of other methods based on antigen detection and nucleic acid amplification, and outline recommendations for future study.
恙虫病通过恙螨传播，流行于东亚、东南亚和澳大利亚北部。典型临床综合征包括发热、皮疹和焦痂，但恙虫病也常表现为不典型发热，需要实验室确诊，通常采用间接荧光抗体（IFA）检测。我们讨论了 IFA 的局限性，对基于抗原检测和核酸扩增的其他方法的价值进行了辩论，并概述了未来研究的建议。
