Bell K M, Cookfair D, Bell D S, Reese P, Cooper L
Monroe County Health Department, Rochester, New York 14692.
Rev Infect Dis. 1991 Jan-Feb;13 Suppl 1:S32-8. doi: 10.1093/clinids/13.supplement_1.s32.
After seven pediatric cases of chronic fatigue syndrome (CFS) were diagnosed in a farming community in upstate New York, a questionnaire regarding symptoms and potential risk factors of CFS was distributed to all students enrolled in the same school district. Twenty-one students with symptoms of CFS were identified. Two controls per case matched for age and sex were randomly selected from questionnaire respondents. Health status was verified for all subjects by telephone, and diagnosis of CFS was confirmed by a physician. Information was collected on the following factors: symptoms of CFS among other family members; history of allergy/asthma; consumption of raw milk, raw eggs, raw cheese, or raw meat; water supply; exposure to animals; home heating source; proximity to farmland/orchards; tick bite; blood transfusion; camping; and appendicitis. Logistic-regression analyses indicated that the best model (characterized by symptoms among other family members, recent ingestion of raw milk, and history of allergy/asthma) produced significant estimates of relative risk (P less than .05) of 35.9, 44.3, and 23.3, respectively, for the three factors (corrections were made for the effect of the other covariates). These data suggest that a combination of host and environmental factors, including an infectious agent or agents, are involved in the etiology of CFS.
在纽约州北部的一个农业社区确诊了7例小儿慢性疲劳综合征（CFS）病例后，一份关于CFS症状和潜在危险因素的问卷被分发给了同一学区内所有注册入学的学生。共识别出21名有CFS症状的学生。从问卷受访者中为每个病例随机选取两名年龄和性别匹配的对照。通过电话核实了所有受试者的健康状况，并由一名医生确诊CFS。收集了以下因素的信息：其他家庭成员中的CFS症状；过敏/哮喘病史；生牛奶、生鸡蛋、生奶酪或生肉的食用情况；供水情况；动物接触史；家庭供暖来源；与农田/果园的距离；蜱叮咬；输血；露营；以及阑尾炎。逻辑回归分析表明，最佳模型（以其他家庭成员中的症状、近期生牛奶摄入以及过敏/哮喘病史为特征）对这三个因素产生的相对风险估计值分别为35.9、44.3和23.3，具有统计学意义（P小于0.05）（已对其他协变量的影响进行校正）。这些数据表明，包括一种或多种传染原在内的宿主和环境因素的组合参与了CFS的病因。
